Genetics of leukocyte telomere length and its role in atherosclerosis
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length is associated with measures of subclinical atherosclerosis.
AIMS Our aim was to test the association of mean leukocyte telomere length (LTL) with ultrasonic measures of subclinical atherosclerosis such as intima-media thickness in the common carotid (IMTcc) and sum of plaque areas (SPA) and with serological markers. METHODS AND RESULTS Carotid and femoral bifurcations were scanned in 762 general population volunteers (46% men) over 40. Four features w...
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RATIONALE Short telomere length (TL) in leukocytes is associated with atherosclerotic cardiovascular disease (ASCVD). It is unknown whether this relationship stems from having inherently short leukocyte TL (LTL) at birth or a faster LTL attrition thereafter. LTL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle represents a minimally replicative tissu...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملHomocysteine levels and leukocyte telomere length.
OBJECTIVE Elevated plasma homocysteine is a risk factor for vascular diseases, possibly due to homocysteine-mediated increase in oxidative stress and inflammation. As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL. METHODS LTL was measured using the Southern blot method. The relationship bet...
متن کاملAberrant leukocyte telomere length in Birdshot Uveitis
PURPOSE Birdshot Uveitis (BU) is an archetypical chronic inflammatory eye disease, with poor visual prognosis, that provides an excellent model for studying chronic inflammation. BU typically affects patients in the fifth decade of life. This suggests that it may represent an age-related chronic inflammatory disease, which has been linked to increased erosion of telomere length of leukocytes. ...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2012
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2011.05.001